Stability of Andes virus and its inactivation by WHO-recommended hand-rub formulations and surface disinfectants

Background: Hantaviruses are responsible for thousands of infections globally. In the absence of vaccines or targeted treatments for severe diseases such as haemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome, medical care focuses solely on managing symptoms. As a result, preventive hygiene measures, such as disinfection, are essential to reduce transmission and minimize the virus's impact on human health. Aim: The aim of this study was to assess the effectiveness of commonly used disinfectants in inactivating Andes virus (ANDV) and evaluate the virus's stabilty to support evidence-based hygiene strategies. Methods: The virucidal activity of hand antiseptics against ANDV was assessed using a quantitative suspension test in accordance with the European guideline EN14476. Surface disinfection efficacy was evaluated according to EN16777 and virus stability was assessed on stainless steel. Conclusion: These findings indicate that ANDV has lower environmental stability compared to other enveloped viruses and can be effectively inactivated by all disinfectants tested. This data can inform risk assessments, especially in areas where hantavirus outbreaks are common, and may guide cleaning protocols for both healthcare environments and high-risk public spaces.