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PublicationIntelligente Biegeverfahren. Entwicklung selbstkorrigierender Fertigungsprozesse in der Umformtechnik( 2015)Ein Schlüssel, die Wirtschaftlichkeit von Biegeverfahren zu steigern, liegt in der Nutzung von Self-X-Technologien. Dabei werden in die heute rein mechanisch gesteuerten Werkzeuge und Maschinen entsprechende Komponenten integriert, welche die kontinuierliche Einhaltung der Soll-Größen sicherstellen. Das Projekt ""Self-X-Pro"" des Spitzenclusters ""it's OWL"" zielt auf die Weiterentwicklung von Biegeverfahren zu intelligenten technischen Systemen, die eine Selbstkorrektur realisieren.
PublicationSchwingungsunterstütztes Stirnschleifen. Schwingungsunterstütztes Schleifen von Gusseisen zur Reduktion kinematisch bedingter Schleifspuren( 2019)In dem Beitrag werden Untersuchungen zur schwingungsunterstützten, kraftgeregelten Feinbearbeitung mit Stirnschleifwerkzeugen zur automatisierten Feinbearbeitung von Gusseisen-Werkzeugproben thematisiert. Ziel ist es, das konventionelle roboter- oder werkzeugmaschinenbasierte Stirnschleifen mit einem schwingungsunterstützten Stirnschleifprozess zu vergleichen. Es werden die Einflüsse der Schwingungsunterstützung auf die Oberflächentopografie mit vordergründigem Ziel einer Minimierung kinematisch bedingter Schleifspuren untersucht.
PublicationAudio captcha breaking and consequences for human users( 2023-01)On the Internet, humans must repeatedly identify themselves to gain access to information or to use services. To check whether a request is sent by a human being and not by a computer, a task must be solved. These tasks are called CAPTCHAs and are designed to be easy for most people to solve and at the same time as unsolvable as possible for a computer. In the context of automated OSINT, which requires automatic solving of CAPTCHAs, we investigate the solving of audio CAPTCHAs. For this purpose, a program is written that integrates two common speech-to-text methods. The program achieves very good results and reaches an accuracy of about 81 percent. As CAPTCHAs are also an important tool for Internet access security, we also use the results of our attack to make suggestions for improving the security of these CAPTCHAs. We compares human listeners with computers and reveal weaknesses of audio CAPTCHAs.
PublicationHallmarks of ion channel gene expression in end-stage heart failure( 2003)Electrical conductance is greatly altered in end-stage heart failure, but little is known about the underlying events. We therefore investigated the expression of genes coding for major inward and outward ion channels, calcium binding proteins, ion receptors, ion exchangers, calcium ATPases, and calcium/calmodulin-dependent protein kinases in explanted hearts (n=13) of patients diagnosed with end-stage heart failure. With the exception of Kv11.1 and Kir3.1 and when compared with healthy controls, major sodium, potassium, and calcium ion channels, ion transporters, and exchangers were significantly repressed, but expression of Kv7.1, HCN4, troponin C and I, SERCA1, and phospholamban was elevated. Hierarchical gene cluster analysis provided novel insight into regulated gene networks. Significant induction of the transcriptional repressor m-Bop and the translational repressor NAT1 coincided with repressed cardiac gene expression. The statistically significant negative correlation between repressors and ion channels points to a mechanism of disease. We observed coregulation of ion channels and the androgen receptor and propose a role for this receptor in ion channel regulation. Overall, the reversal of repressed ion channel gene expression in patients with implanted assist devices exemplifies the complex interactions between pressure load/stretch force and heart-specific gene expression.
PublicationQSARs of bioconcentration - validity assessment of log Pow / log BCF correlations( 1991)The bioconcentration factor (BCF) is an important parameter for the assessment of chemical substances in ecosystems. Chemical legislation does not request any experimental determination of bioconcentration potential in the basic tier, but relies on extrapolations from the compounds-1-octanol/water partition coefficient (log PsubOW) assuming a positive correlation between log PsubOW and log BCF. Substances with log PsubOW between 3 and 6 are classified highly accumulating; no substantial bioconcentration is assumed for compounds having log PsubOW smaller than 3 or bigger than 6. Basically, this assessment scheme represents the application of quantitative structure- activity relationships (QSARs) for legislative purposes. Considering that bioaccumulation is an equilibrium distribution between an organism, e.g. fish, and the surrounding water phase it seems reasonable that the BCF is estimated from other partition coefficients, namely log PsubOW. This concept is supported by numerous publ ications reporting linear log PsubOW/BCF correlations. To test the validity of the postulated log PsubOW/log BCF correlations, published BCF values were validated and compared with the respective calculated log PsubOW values generally revealing increasing BCF values with increasing log PsubOW. For compounds having log PsubOW bigger than 6 a gradual decrease of the BCF is found. The significance of the correlation however is not as high as could be assumed from the results found in the literature.
PublicationJoining, texturing, modifying: Selecting the right laser( 2005)While the use of laser technology was often limited to expensive products in the past, inexpensive diode lasers and more compact Nd:YAG lasers are finding an ever-wider field of application in the plastics industry. For every specific application, the question always arises as to what is the right laser beam.