• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Design of the formalized and integrated Alzheimer's Disease Ontology and its application in retrieving textual data via text mining
 
  • Details
  • Full
Options
2023
Journal Article
Title

Design of the formalized and integrated Alzheimer's Disease Ontology and its application in retrieving textual data via text mining

Abstract
As one of the leading causes for dementia in the population, it is imperative that we discern exactly why Alzheimer’s disease (AD) has a strong molecular association with beta-amyloid and tau. Although a clear understanding about etiology and pathogenesis of AD remains unsolved, scientists worldwide have dedicated significant efforts to discovering the molecular interactions linked to the pathological characteristics and potential treatments. Knowledge representations, such as domain ontologies encompassing our current understanding about AD, could greatly assist and contribute to disease research. This paper describes the construction and application of the integrated Alzheimer’s Disease Ontology (ADO), combining selected concepts from the former version of the ADO and the Alzheimer’s Disease Mapping Ontology (ADMO). In addition to the existing entities available from these knowledge models, essential knowledge about AD from public sources, such as newly discovered risk factor genes and novel treatments, was also integrated. The ADO can also be leveraged in text mining scenarios given that it is conceptually enriched with domain-specific knowledge as well as their relations. The integrated ADO consists of 39 855 total axioms. The ontology covers many aspects of the AD domain, including risk factor genes, clinical features, treatments and experimental models. The ontology complies with the Open Biological and Biomedical Ontology principles and was accepted by the foundry. In this paper, we illustrate the role of the presented ontology in extracting textual information from the SCAIView database and key measures in an ADO-based corpus.
Author(s)
Zhang, Bide
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Lage-Rupprecht, Vanessa
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Wegner, Philipp
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Sargsyan, Astghik  
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Gebel, Stephan
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Jacobs, Marc  
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Klein, Jürgen
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Hofmann-Apitius, Martin  
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Tom Kodamullil, Alpha
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Journal
Database  
Open Access
DOI
10.1093/database/baad085
Language
English
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
Keyword(s)
  • Alzheimer's disease

  • Ontology

  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024