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PublicationPlattform für einen sektorenübergreifenden Austausch von Transport- und Energiedaten( 2024)Die Elektrifizierung des straßengebundenen Gütertransports stellt den Logistik- und Energiesektor vor große Herausforderungen. Um Transportunternehmen bedarfsgerecht und zuverlässig mit elektrischer Energie versorgen zu können, müssen Informationen branchenübergreifend verarbeitet werden können. Im mFUND-Forschungsprojekt TruckConnect der Universität Stuttgart wurden die betreffenden Akteure identifiziert und ihre Rollen analysiert sowie eine zentrale Plattform für den erforderlichen Datenaustausch konzipiert.
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PublicationCovalent Trapping of Cyclic-Polysulfides in Perfluorinated Vinylene-Linked Frameworks for Designing Lithium-Organosulfide Batteries( 2023)The strategic combination of redox-active triazine- or quinoxaline-based lithium-ion battery (LIB) mechanisms with the polysulfide ring-mediated lithium-sulfur battery (Li-SB) mechanism enabled the configuration of covalent organic-framework (COF)-derived lithium-organosulfide (Li-OrSB) battery systems. Two vinylene-linked frameworks were designed by enclosing polysulfide rings via postsynthetic framework sulfurization, allowing for the separate construction of triazine-polysulfide and quinoxaline-polysulfide redox couples that can readily interact with Li ions. The inverse vulcanization of the vinylene linking followed by the sulfurization-induced nucleophilic aromatic substitution reaction (SNAr) on the perfluorinated aromatic center of the COFs enabled the covalent trapping of cyclic-polysulfides. The experimentally observed reversible Li-interaction mechanism of these highly conjugated frameworks was computationally verified and supported by in situ Raman studies, demonstrating a significant reduction of polysulfide shuttle in a conventional Li-SB and opening the door for a COF-derived high-performing Li-OrSB.
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PublicationRapid phenotypic antibiotics susceptibility analysis by a 3D printed prototype( 2024)One of the most important public health concerns is the increase in antibiotic‐resistant pathogens and corresponding treatment of associated infections. Addressing this challenge requires more efficient use of antibiotics, achievable by the use of evidence‐based, effective antibiotics identified by antibiotic susceptibility testing (AST). However, the current standard method of phenotypic AST used for this purpose requires 48 h or more from sample collection to result. Until results are available, broad‐spectrum antibiotics are used to avoid delaying treatment. The turnaround time must therefore be shortened in order for the results to be available before the second administration of antibiotics. The phenotypic electrochemical AST method presented here identifies effective antibiotics within 5-10 h after sampling. Spiked serum samples, including polymicrobial samples, with clinically relevant pathogens and respective concentrations commonly found in bloodstream infections (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa) are used. Direct loading of the test with diluted serum eliminates the need for a pre‐culture, as required by existing methods. Furthermore, by combining several electrochemical measurement procedures with computational analysis, allowing the method to be used both online and offline, the AST achieves a sensitivity of 94.44% and a specificity of 95.83% considering each replicate individually.
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PublicationIn vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy( 2024)Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseudomonal infections. Phages are not only bactericidal but occasionally show activity against biofilm as well. In this study, we describe the Pseudomonas phage Motto, a T1-like phage that can clear P. aeruginosa infections in an animal model and also exhibits biofilm-degrading properties. The phage has a substantial anti-biofilm activity against strong biofilm-producing isolates (n = 10), with at least a twofold reduction within 24 h. To demonstrate the safety of using phage Motto, cytotoxicity studies were conducted with human cell lines (HEK 293 and RAW 264.7 macrophages). Using a previously established in vivo model, we demonstrated the efficacy of Motto in Caenorhabditis elegans, with a 90% survival rate when treated with the phage at a multiplicity of infection of 10.
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PublicationOn the Corrosion Properties of Aluminum 2024 Laser‐Textured Surfaces with Superhydrophilic and Superhydrophobic Wettability States( 2023)In this work, the mechanism of the corrosion behavior of laser-treated aluminum is studied. Two different laser techniques are used to fabricate the samples, direct laser interference patterning (DLIP) and direct laser writing (DLW), using nanosecond laser sources. The DLIP treatment uses a two-beam optical configuration producing line-like periodic structures. The DLW technique is employed to produce non-periodic structures on the Al-surface with the same cumulated fluences as in DLIP. The surface topography is analyzed by confocal microscopy, and the formation of oxide layers is investigated by scanning electron microscopy of cross-sections produced using a focused ion beam. Wetting measurements performed on the laser-treated samples exhibit a contrasting behavior, leading to either superhydrophobic or superhydrophilic states. In the case of the DLIP treatment, the static water contact angle is increased from 81° up to 158°, while for DLW, it decreases to 3°. Electrochemical tests demonstrate a decreased corrosion rate after laser treatment. Additionally, findings indicate no correlation between wettability and corrosion reduction. Therefore, the improvement in corrosion resistance is mainly attributed to the oxide layer formed by laser treatment. Although similar corrosion rates are achieved for both treatments, surfaces produced with DLIP can be beneficial when additional surface properties are required.