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  4. Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties
 
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October 1, 2024
Journal Article
Title

Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties

Abstract
Prosthesis loosening due to lack of osteointegration between an implant and surrounding bone tissue is one of the most common causes of implant failure. Further, bacterial contamination and biofilm formation onto implants represent a serious complication after surgery. The enhancement of osteointegration can be achieved by using bioconductive materials that promote biological responses in the body, stimulating bone growth and thus bonding to tissue. Through the incorporation of antibacterial substances in bioconductive, biodegradable calcium phosphate (CaP) coatings, faster osteointegration and bactericidal properties can be achieved. In this study, Cu-doped CaP supraparticles are spray-dried and suspension-sprayed CaP ceramic coatings with antibacterial properties are prepared using high-velocity suspension flame spraying (HVSFS). The objective was to increase the coatings’ porosity and investigate which Cu-doped supraparticles have the strongest antibacterial properties when introduced into the coating layers. Biocompatibility was tested on human Osteosarcoma cells MG63. A porosity of at least 13% was achieved and the supraparticles could be implemented, enhancing it up to 16%. The results showed that the addition of Cu-doped supraparticles did not significantly reduce the number of viable cells compared to the Cu-free sample, demonstrating good biocompatibility. The antimicrobial activity was assessed against the bacterial strains Escherichia coli and Staphylococcus aureus, with Safe Airborne Antibacterial testing showing a significant reduction in both Gram-positive and Gram-negative strains on the Cu-doped coatings.
Author(s)
Lanzino, Maria Carolina
University of Stuttgart, Institute for Manufacturing Technologies of Ceramic Components and Composites (IFKB)
Le, Long-Quan R.V.
Albert-Ludwigs-University of Freiburg, G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine
Höppel, Anika
Killinger, Andreas
Rheinheimer, Wolfgang
Dembski, Sofia  
University Hospital Würzburg, Department of Tissue Engineering and Regenerative Medicine (TERM)
Al-Ahmad, Ali
Albert-Ludwigs-University of Freiburg, Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Faculty of Medicine
Mayr, Hermann O.
Albert-Ludwigs-University of Freiburg, G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine
Seidenstuecker, Michael
Albert-Ludwigs-University of Freiburg, G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine
Journal
Journal of Functional Biomaterials  
Open Access
DOI
10.3390/jfb15100281
Language
English
Fraunhofer-Institut für Silicatforschung ISC  
Keyword(s)
  • antimicrobial activity

  • CaP

  • coating

  • joint

  • supraparticles

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