A Cell-Type Selective Stimulation and Recording System for Retinal Ganglion Cells

Future retinal implants will require a stimulation selectivity between different sub-types of Retinal Ganglion Cells (RGCs) to evoke natural perceptions rather than phosphenes in patients. To achieve this, a cell-type specific stimulation pipeline is required that identifies target RGC sub-types from recorded input images and extracts the specific stimulation parameters to activate this cell-type selectively. Promising biological experiments showed that ON-/OFF-sustained/transient RGCs could be selectively activated by modulating repetition rate and amplitude of an electrical stimulation current in the kilohertz range. This research presents a 42 channel current controlled stimulation and recording system on chip (SoC) with parameter input from a real time target RGC selection algorithm. The SoC is able to stimulate retinal tissue with sinusoidal frequencies higher than 1 kHz at amplitudes of up to 200 µA at a supply voltage of 1.8 V. It also includes tunable recording units with an integrated action potential detection pipeline that are able to amplify signals between 1 Hz and 50 kHz. The required area of one stimulator is 0.0071 mm 2 , while one recording unit consumes an area of 0.0092 mm 2. The application of sinusoidal stimulation currents in the kilohertz range towards retinal tissue leads to a suppressive response of only certain RGC sub-types that has not been oberved before, using electrical stimulation. Because this response is very similar to the natural light response of RGCs, this stimulation approach can lead to a more genuine visual perception for patients using retinal implants.