• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities
 
  • Details
  • Full
Options
2016
Book Article
Title

Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities

Abstract
During the last few years tailored therapies have improved overall survival of patients with metastatic disease. However, iatrogenic selection pressure continues to drive the evolution of systemically spread cancer cells, resulting in the generation of aggressive and therapy-resistant tumor cells. The outcome is cancer relapse and death in the majority of patients. In early disease stages, (neo) adjuvant targeted therapies often fail for unknown reasons. Therefore, diagnostic and therapeutic strategies have to be reevaluated on the basis of an evolutionary concept of disease. This obviously implies the ability to monitor the molecular evolution of the disease. To this end, a novel diagnostic pathology for systemic cancer has to be developed that will enable precision medicine for cancer patients.
Author(s)
Polzer, Bernhard
Universität Regensburg  
Klein, Christoph Andreas  
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM  
Mainwork
Circulating Tumor Cells. Advances in Basic Science and Clinical Applications  
DOI
10.1007/978-1-4939-3363-1_14
Language
English
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM  
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024