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  4. Human endothelial cells form an endothelium in freestanding collagen hollow filaments fabricated by direct extrusion printing
 
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2022
Journal Article
Title

Human endothelial cells form an endothelium in freestanding collagen hollow filaments fabricated by direct extrusion printing

Abstract
Fiber-shaped materials have great potential for tissue engineering applications as they provide structural support and spatial patterns within a three-dimensional construct. Here we demonstrate the fabrication of mechanically stable, meter-long collagen hollow filaments by a direct extrusion printing process. The fibres are permeable for oxygen and proteins and allow cultivation of primary human endothelial cells (ECs) at the inner surface under perfused conditions. The cells show typical characteristics of a well-organized EC lining including VE-cadherin expression, cellular response to flow and ECM production. The results demonstrate that the collagen tubes are capable of creating robust soft tissue filaments. The mechanical properties and the biofunctionality of these collagen hollow filaments facilitate the engineering of prevascularised tissue engineering constructs.
Author(s)
Prade, Ina
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Schröpfer, Michaela
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Seidel, Caroline
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Krumbiegel, Claudia
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Hille, Tina
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Sonntag, Frank  orcid-logo
Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS  
Behrens, Stephen
Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS  
Schmieder, Florian  
Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS  
Voigt, Birgit
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Meyer, Michael
Forschungsinstitut für Leder- und Kunstledertechnologie -FILK-, Freiberg  
Journal
Biomaterials and biosystems  
Open Access
DOI
10.1016/j.bbiosy.2022.100067
Language
English
Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS  
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