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2019
Conference Paper
Titel
Quality-by-Design: Monte-Carlo Simulation Accounting for Real-World Liquid Handling and Manufacture Tolerances towards Robust Microfluidic Architectures
Abstract
The functionality of microfluidic systems is often sensitively impacted by real-world effects such as inaccuracies in the definition of liquid volumes and geometries. While systematic deviations like thermal shrinkage may be compensated by proper design, statistical errors may significantly impair functionality, particularly when resulting errors propagate through concatenated functional elements in integrated microfluidic networks.
In this paper we systematically investigate how such physical errors originating from manufacturing fidelity and pipetting affect the performance of buoyancy-driven centripetal pumping, as well as their impact on multi-step protocols. In this specific example, the impact of such tolerances on the accuracy of the centripetally pumped vol-umes and the required amount of consumption of ancillary, high-density pumping liquid are characterised. Our underlying Monte-Carlo methodology can readily be generalised for other microfluidic architectures.
Author(s)
Kinahan, David
2FPC@DCU ā Fraunhofer Project Centre for Embedded Bioanalytical Systems at Dublin City University