• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
 
  • Details
  • Full
Options
2022
Journal Article
Title

Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo

Abstract
The high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt–chromium (CoCr) alloy tubes, which are used for coronary stent manufacturing, were prepared with a coating of polylactic acid (PLA) which contained either modified or non-modified Fe@C NPs in a 5% by weight concentration. The tubes were implanted into an area of subcutaneous fat in Wistar rats, where changes in the histological structure and functional properties of the surrounding tissue were observed in the case of coatings modified with Fe@C NPs. For the ex vivo study, freshly explanted human atherosclerotic plaques were treated in the physiological solution with doses of modified Fe@C NPs, with mass equal to 5% or 25% relative to the plaques. This treatment resulted in the release of cholesterol-like compounds from the surface of the plaques into the solution, thus proving a pronounced destructive effect on the plaque structure. Chemically modified Fe@C NPs, when used as an anti-atherosclerosis agent, were able to activate the activity of macrophages, which could lead to the destruction of atherosclerotic plaques structures. These findings could prove the fabrication of next-generation vascular stents with built-in anti-atherosclerotic agents.
Author(s)
Akhmedov, Shamil
Russian Academy of Sciences  
Afanasyev, Sergey
Russian Academy of Sciences  
Beshchasna, Natalia  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Trusova, Marina
Tomsk Politechnical University  
Stepanov, Ivan
Russian Academy of Sciences  
Rebenkova, Mariya
Russian Academy of Sciences  
Poletykina, Ekaterina
Tomsk Politechnical University  
Vecherskiy, Yuri
Russian Academy of Sciences  
Tverdokhlebov, Sergei
Tomsk Politechnical University  
Bolbasov, Evgeny
Tomsk Politechnical University  
Balakin, Sascha  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Opitz, Jörg  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Yermakov, Anatoly
Russian Academy of Sciences  
Kozlov, Boris
Russian Academy of Sciences  
Journal
International journal of molecular sciences  
Open Access
DOI
10.3390/ijms23158241
Language
English
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Keyword(s)
  • atherosclerosis

  • atherosclerotic plaque

  • chemically modified carbon-coated iron nanoparticle

  • reverse cholesterol transport

  • macrophage

  • coronary stent

  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024