Modeling Clinical Practice Guidelines for Interactive Decision Support Exemplified by Primary Myelofibrosis and Immune Thrombocytopenia

Clinical Practice Guidelines (CPGs) contain ex-pert knowledge on the diagnosis and treatment of diseases. They can be regarded as state of the art and standardized procedures that have been established by consensus of the clinical expert community. In this work, we show how CPGs can be formalized by activities of the Unified Modeling Language (UML), and can subsequently be translated into PROforma models. UML activities allow for a comprehensible representation of the underlying process, whereas PROforma models can be directly executed in a dialog system and support the practitioner during the diagnosis or treatment process. In this work, we expand our approach from [1] to include more complex diseases like Primary Myelofribrosis (PMF) and Immune Thrombocytopenia (ITP) and show the applicability for exemplary patients.