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  4. Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch-Spun Poly(Ester-Urethane) Elastomer
 
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2022
Journal Article
Titel

Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch-Spun Poly(Ester-Urethane) Elastomer

Abstract
Development of fiber-spinning technologies and materials with proper mechanical properties is highly important for the manufacturing of aligned fibrous scaffolds mimicking structure of the muscle tissues. Here, the authors report touch spinning of a thermoplastic poly(1,4-butylene adipate)-based polyurethane elastomer, obtained via solvent-free polymerization. This polymer possesses a combination of important advantages such as 1) low elastic modulus in the range of a few MPa, 2) good recovery ratio and 3) resilience, 4) processability, 5) nontoxicity, 6) biocompatibility, and 7) biodegradability that makes it suitable for fabrication of structures mimicking extracellular matrix of muscle tissue. Touch spinning allows fast and precise deposition of highly aligned micro- and nano-fibers without use of high voltage. C2C12 myoblasts readily align along soft polymer fibers and demonstrate high viability as well as proliferation that make proposed combination of polymer and fabrication method highly suitable for engineering skeletal muscles.
Author(s)
Uribe-Gomez, Juan
University of Bayreuth - Faculty of Engineering Sciences and Bavarian Polymer Institute
Schönfeld, Dennis
Fraunhofer-Institut für Angewandte Polymerforschung IAP
Andrés Posada-Murcia
University of Bayreuth - Faculty of Engineering Sciences and Bavarian Polymer Institute
Michel-Manuel, Roland
University of Bayreuth - Faculty of Engineering Sciences and Bavarian Polymer Institute
Caspari, Anja
Leibniz-Institut für Polymerforschung Dresden e.V.
Synytska, Alla
Leibniz-Institut für Polymerforschung Dresden e.V., Technische Universität Dresden - Fakultät Mathematik und Naturwissenschaften, Universität Bayreuth - Bayerisches Polymerinstitut BPI
Salehi, Sahar
University of Bayreuth - Department of Biomaterials
Pretsch, Thorsten
Fraunhofer-Institut für Angewandte Polymerforschung IAP
Ionov, Leonid
University of Bayreuth - Faculty of Engineering Sciences and Bavarian Polymer Institute
Zeitschrift
Macromolecular bioscience
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DOI
10.1002/mabi.202100427
Language
English
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Fraunhofer-Institut für Angewandte Polymerforschung IAP
Tags
  • biofabrication

  • microfibers

  • poly(ester-urethane)

  • skeletal muscle

  • touch-spinning

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