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  4. Evaluation of impedance spectroscopy for the characterization of small biological samples in tissue-based test systems
 
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2004
Conference Paper
Title

Evaluation of impedance spectroscopy for the characterization of small biological samples in tissue-based test systems

Abstract
Marker free techniques are needed for the construction of efficient tissue-based test and sensor systems. In principle biological tissue can be characterized by impedance spectroscopy. In this paper we investigate by simulation how sensitive parameters of small biological tissue samples can be determined by impedance spectroscopy under optimal measurement conditions. Further, we experimentally evaluate whether the effects of different clinical relevant radio therapy variants on 3D in vitro tumor models are determinate and distinguishable by impedance spectroscopy using a tissue-based test system. The simulations demonstrate that changes in tissue parameters related to the extracellular space are determinable with a high sensitivity. The experiments show that the effect of different radiation dose levels on 3D in vitro tumor models can be determined and distinguished by using a capillary measurement system and impedance spectroscopy. These results are relevant for the de velopment of tissue-based test and sensor systems using impedance spectroscopy to evaluate personalized therapy variants or new therapy approaches.
Author(s)
Thielecke, H.
Fleckenstein, J.
Bartholomä, P.
Rübe, C.
Mainwork
Linkages for innovation in biomedicine. 26th annual international conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004. Vol.3  
Conference
Engineering in Medicine and Biology Society (EMBS International Conference) 2004  
DOI
10.1109/IEMBS.2004.1403608
Language
English
Fraunhofer-Institut für Biomedizinische Technik IBMT  
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