Magnetische Manipulation von biologischen Proben

Es wird ein Zelltraeger (10) zur Aufnahme einer biologischen Probe beschrieben, der ein Magnetelement (20) aufweist, wobei ein Bodenelement (30) vorgesehen ist, das eine stabile, auf einer festen Basisflaeche in mindestens einer Richtung verschiebbare Auflage (31) bildet. Es werden auch eine Manipulationseinrichtung fuer biologische Proben und Verfahren zur Manipulation biologischer Proben beschrieben.

WO2005083057 A UPAB: 20051011 NOVELTY - Cell carrier (10) for receiving a biological sample that includes a magnetic component (20). DETAILED DESCRIPTION - Cell carrier (10) for receiving a biological sample comprises a magnetic component (20); a foundation element (30) that forms a solid support, moveable in at least one direction on a solid base, and a receiving element (40) that has a surface (41) for holding the sample. (40) is on the opposite side from (30) and is formed to promote adhesion in a predetermined partial region of (41). INDEPENDENT CLAIMS are also included for the following: (1) culture carrier (50) for receiving biological cell that comprises many (10); (2) device (60) for manipulating biological samples comprising a solid base (10); (61) arranged for positioning of at least one (10) and a positioning device (70) for exerting a magnetic force on (10); and (3) manipulating biological samples comprising placing a sample on (10) then moving (10) by applying a magnetic force. USE - The carrier is used in automated culture and processing of cells and/or cell components, e.g. cells for therapeutic use, but more generally in biochemical, genetic engineering, medical and biological applications. ADVANTAGE - Compared with usual microfluidics systems, (10) provides a more flexible system, including manipulation of individual adherent cells under sterile conditions, without application of a force to the cell itself. The use of a solid support avoids problems of non-reproducible aggregation encountered when using microbeads. 6