Verwendung von 5' substituierten Nukleosiden zur Hemmung von Resistenzbildung bei der Zytostatikabehandlung und Arzneimittel, enthaltend diese Nukleotide

The use of 5-substd. nucleosides (I) in combination with at least one cytostatic agent (II) is claimed for prepn. of a medicament for preventing or inhibiting the development of resistance in cytostatic therapy. Also claimed is a medicament contg. (I) in an amt. giving a blood concn. of 0.02-10 (pref. 0.05-5) mug/ml, at least one (II) and conventional carriers and additives. (I) is e.g. (E)-5-(2-bromovinyl)-2'-deoxyuridine and (II) is selected from alkaloids, alkylating agents, antimetabolites, antibiotics and cisplatin. USE - The medicaments are used in the chemotherapy of cancer. ADVANTAGE - (I) inhibit or reduce carcinogen-induced gene amplification, and thus reduce both the development or resistance to (II) and the degree of malignity.