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2021
Journal Article
Title
Haemocompatibility testing allows selective adaption of GA-free SULEEI-preparation strategy for bovine pericardium
Abstract
Bovine pericardium is the main natural source for patches or valve substitutes in cardiac surgery, but still, long-term durability is limited. An alternative, glutaraldehyde (GA)-free preparation combining decellularization, riboflavin/UVA crosslinking, and low-energy electron irradiation (SULEEI) procedure was established to avoid this. Protocol optimization is ongoing to further improve the final material. Haemocompatibility in vitro testing with fresh, human whole blood has advantages for material analysis, as it provides essential information on the activation of the complement system and immune cells therefore substantiating and possibly reducing the amount of animal testing.
Author(s)
Dittfeld, C.
Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany
Welzel, C.
Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany
Jannasch, A.
Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany
Matschke, K.
Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany
Sperling, C.
Leibniz-Institut für Polymerforschung Dresden e.V., Institute Biofunctional Polymermaterials, Dresden, Germany
Tugtekin, S.-M.
Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany