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  4. Piezoelectric Silicon Micropump for Drug Delivery Applications
 
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2021
Zeitschriftenaufsatz
Titel

Piezoelectric Silicon Micropump for Drug Delivery Applications

Abstract
Subcutaneous injection is crucial for the treatment of many diseases. Especially for regular or continuous injections, automated dosing is beneficial. However, existing devices are large, uncomfortable, visible under clothing, or interfere with physical activity. Thus, the development of small, energy efficient and reliable patch pumps or implantable systems is necessary and research on microelectromechanical system (MEMS) based drug delivery devices has gained increasing interest. However, the requirements of medical applications are challenging and especially the dosing precision and reliability of MEMS pumps are not yet sufficiently evaluated. To enable further miniaturization, we propose a precise 5 × 5 mm2 silicon micropump. Detailed experimental evaluation of ten pumps proves a backpressure capability with air of 12.5 ± 0.8 kPa, which indicates the ability to transport bubbles. The maximal water flow rate is 74 ± 6 µL/min and the pumps' average blocking pressure is 51 kPa. The evaluation of the dosing precision for bolus deliveries with water and insulin shows a high repeatability of dosed package volumes. The pumps show a mean standard deviation of only 0.02 mg for 0.5 mg packages, and therefore, stay below the generally accepted 5% deviation, even for this extremely small amount. The high precision enables the combination with higher concentrated medication and is the foundation for the development of an extremely miniaturized patch pump.
Author(s)
Bußmann, Agnes
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Leistner, Henry
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Zhou, Doris
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Wackerle, Martin
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Congar, Yücel
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Richter, Martin
Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien EMFT
Hubbuch, Jürgen
Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany
Zeitschrift
Applied Sciences
Project(s)
Moore4Medical
Funder
European Commission EC
Thumbnail Image
DOI
10.3390/app11178008
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Externer Link
Language
Englisch
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