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2021
Journal Article
Title
The rationale behind implant coatings to promote osteointegration, bone healing or regeneration
Abstract
Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. Implant surface modifications and coatings are being developed to promote osteointegration, prevent colonization by bacteria, and release bioactive factors. The following mini-review briefly discusses the clinical problem, explains the four ""osteos"", presents examples of coatings used for different orthopedic indications, and finally raises awareness of the coating and translational requirements.
Author(s)
Schmidmaier, Gerhard
Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital,
Hofmann, Gunther O.
Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena
Wildemann, Britt
Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena; Julius Wolff Institute, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health