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  4. Grafting from a hybrid DNA-covalent polymer by the hybridization chain reaction
 
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2018
Journal Article
Title

Grafting from a hybrid DNA-covalent polymer by the hybridization chain reaction

Abstract
Nucleic acid-polymer conjugates are an attractive class of materials endowed with tunable and responsive character. Herein, we exploit the dynamic character of nucleic acids in the preparation of hybrid DNA-covalent polymers with extendable grafts by the hybridization chain reaction. Addition of DNA hairpins to an initiator DNA-dextran graft copolymer resulted in the growth of the DNA grafts as evidenced by various characterization techniques over several length scales. Additionally, aggregation of the initiator DNA-graft copolymer before the hybridization chain reaction was observed resulting in the formation of kinetically trapped aggregates several hundreds of nanometers in diameter that could be disrupted by a preheating step at 60 °C prior to extension at room temperature. Materials of increasing viscosity were rapidly formed when metastable DNA hairpins were added to the initiator DNA-dextran grafted copolymer with increasing concentration of the components in the mixture. This study shows the potential for hierarchical self-assembly of DNA-grafted polymers through the hybridization chain reaction and opens the door for biomedical applications where viscosity can be used as a readout.
Author(s)
Noteborn, Willem E.M.
Wondergem, Joeri A.J.
Iurchenko, Anastasiia
Chariyev-Prinz, Farhad
Donato, Dominique
Voets, Ilja K.
Heinrich, Doris  
Fraunhofer-Institut für Silicatforschung ISC  
Kieltyka, Roxanne E.
Journal
Macromolecules  
Open Access
DOI
10.1021/acs.macromol.7b02610
Language
English
Fraunhofer-Institut für Silicatforschung ISC  
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