• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): A web server for mechanism enrichment
 
  • Details
  • Full
Options
2017
Journal Article
Title

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): A web server for mechanism enrichment

Abstract
Motivation: The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.
Results: We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a 'mechanism-enrichment server' that supports the mechanistic interpretation of multiscale, multimodal clinical data. Availability and implementation: NeuroMMSig is available at http://neurommsig.scai.fraunhofer.de/
Author(s)
Domingo-Fernández, Daniel
Kodamullil, Alpha Tom
Iyappan, Anandhi
Naz, Mufassra
Emon, Mohammad Asif
Raschka, Tamara  
Karki, Reagon  
Springstubbe, Stephan  
Ebeling, Christian  
Hofmann-Apitius, Martin  
Journal
Bioinformatics  
DOI
10.1093/bioinformatics/btx399
Additional full text version
Landing Page
Language
English
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI  
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024