• English
  • Deutsch
  • Log In
    Password Login
    or
  • Research Outputs
  • Projects
  • Researchers
  • Institutes
  • Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Of mice and men: Comparative analysis of neuro-inflammatory mechanisms in human and mouse using cause-and-effect models
 
  • Details
  • Full
Options
2017
Journal Article
Titel

Of mice and men: Comparative analysis of neuro-inflammatory mechanisms in human and mouse using cause-and-effect models

Abstract
Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited access of human brain tissues and the immense complexity of the brain, animal models, specifically mouse models, play a key role in advancing the NDD field. However, many of these mouse models fail to reproduce the clinical manifestations and end points of the disease. NDD drugs, which passed the efficacy test in mice, were repeatedly not successful in clinical trials. There are numerous studies which are supporting and opposing the applicability of mouse models in neuroinflammation and NDD. In this paper, we assessed to what extend a mouse can mimic the cellular and molecular interactions in humans at a mechanism level. Based on our mechanistic modeling approach, we investigate the failure of a neuroinflammation targeted drug in the late phases of clinical trials based on the comparative analyses between the two species.
Author(s)
Kodamullil, A.T.
Iyappan, A.
Karki, R.
Madan, S.
Younesi, E.
Hofmann-Apitius, M.
Zeitschrift
Journal of Alzheimer's disease : JAD
Thumbnail Image
DOI
10.3233/JAD-170255
Externer Link
Externer Link
Language
English
google-scholar
Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Send Feedback
© 2022