Pharmacodynamic modeling of changes in pulse waveform during induction of propofol anaesthesia in volunteers

Propofol anaesthesia causes changes in pulse pressure waveform. Features of pulse pressure waveform from radial artery are associated with blood flow properties of central arteries and left ventricular heart function. Since maintenance of stable hemodynamics is one of the main goals of adequate anaesthesia, non-invasive monitoring of pulse waveform parameters may contribute additional information to routine measurement of arterial blood pressure. Continuous non-invasive finger blood pressure recordings performed with Task Force Monitor® (TFM) provide real-time pulse pressure waveforms. In this exploratory study, we estimated propofol induced changes in three pulse waveform parameters during induction of anaesthesia by pharmacokinetic/-dynamic (Pk/Pd) modeling and examined whether Pd parameters fitted with noninvasive measurements were similar to those fitted with invasive measurements from radial artery.