Kidney transplant from the same donor without maintenance immunosuppression after previous hematopoietic stem cell transplant

In January 2005, an 18-year-old male patient with acute myeloid leukemia (AML) received a haploidentical hematopoietic stem cell transplantation (HSCT) from his father. He developed hemolytic uremic syndrome and end-stage renal disease (ESRD) requiring hemodialysis on day 357 after HSCT. On day 1020 after HSCT, a living kidney donation from the stem cell donor was carried out. The creatinine before kidney transplantation (KT) was 450 mol/L, 268 mol/L on day 2 after KT, 88 M on day 38 and 89 mol/L on day 960 (day 1980 after HSCT). Immunosuppression was gradually discontinued: cortisone on day 28, tacrolimus on day 32 and MMF on day 100 after KT (day 1120 after HSCT). As of June 2010, 66 months after HSCT and 32 months after KT, the patient has had neither rejection episodes nor clinical manifestations of transplantation-related complications. The patient reached 100% hematopoietic donor chimerism prekidney transplant and retained this state postkidney transplant. This un ique case is the first report of a successful kidney transplant without immunosuppression after HSCT from the same haploidentical donor. The authors present a case in which haploidentical hematopoietic stem cell transplant for acute myeloid leukemia allowed for kidney transplantation from the same donor without maintenance immunosuppression.