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  4. Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyromycin
 
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1988
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Titel

Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyromycin

Abstract
The oligosaccharide-anthracyclines, aclacinomycin A, marcellomycin and musettamycin, are potent inducers of erythroid differentiation in hemopoietic cell lines of rodent and human origin. The present studies revealed that pyrromycin, a closely related mono-saccharide-anthracycline, induced erythroid differentiation in Friend leukemia cells and in the human leukemia cell line K 562. Pyrromycin, marcellomycin and musettamycin, which possess an identical aglycone structure containing a Cl-hydroxyl group, exhibited relatively low optimal inductive concentrations. In contrast, the optimal inductive concentration of a aclacinomycin A, which lacks the Cl-hydroxyl group, was markedly higher, i.e., the differentiation inducing capacity was lower. It should be noted, however, that the yield of differentiated cells following treatment with the monosaccharide-anthracycline pyrromycin was distinctly lower than that after treatment with the oligo-saccharide-anthracyclines, aclacinomycin A, marcellom ycin or mussettamycin. Thus, our data indicate that the efficacy of anthracyclines to induce erythroid differentiation is related to a) the presence of a Cl-hydroxyl group in the aglycone and b) the presence of an oligosaccharide side chain.
Author(s)
Schäfer, A.
Marquardt, H.
Steinheider, G.
Westendorf, J.
Zeitschrift
Cell Biology and Toxicology
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Language
Englisch
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Tags
  • anthracycline

  • cell line

  • DNA

  • erythroid differentia...

  • hemopoietic cell line...

  • leukemia cell

  • pyrromycin

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