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  4. Human embyronic/atrial myosin alkali light chain gene. Characterization, sequence, and chromosomal location
 
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1990
Journal Article
Title

Human embyronic/atrial myosin alkali light chain gene. Characterization, sequence, and chromosomal location

Abstract
We have isolated and sequenced the gene encoding the human embryonic/atrial myosin alkali light chain isoform (MLC-1emb/A). The gene is split into seven exons by six introns. The last exon, as in all MLC isoform genes sequenced to date, is completely 3'untranslated sequence. Comparison of the MLC-1emb/A isoform gene with the other MLC-1 genes showed that the exon-intron arrangement of the human MLC-1emb/A isoform gene is analogous to that of the other MLC-1 type isoform genes. We have also mapped the human MLC-1emb/a isoform gene to the long arm of chromosome 17. The corresponding mouse gene has been mapped to chromosome 11. This gene, together with a number of others such as the collagen alpha 1, galactokinase, and thymidine kinase genes, is part of the largest syntenic group between mouse and man.
Author(s)
Arnold, H.-H.
Bober, E.
Fodor, W.L.
Francke, U.
Hsieh, C.-L.
Seharaseyon, J.
Vanin, E.F.
Journal
Genomics  
Language
English
ITA  
Keyword(s)
  • amino acid sequence

  • base sequence

  • chromosome mapping

  • chromosomes

  • exon

  • gene

  • genetic

  • human chromosome 17

  • MLC-1 gene

  • mosin alkali light chain gene

  • myosin

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