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  4. Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity
 
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2015
Journal Article
Title

Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity

Abstract
Loss of articular cartilage surface integrity is considered the earliest sign of osteoarthritis; however, its reliable detection has not been established by clinical routine diagnostics. This study comprehensively assesses a set of 11 algorithm-based 2-D Optical Coherence Tomography roughness parameters and investigates their clinical impact. Histology and manual irregularity quantification of 105 human cartilage samples with variable degeneration served as reference. The majority of parameters revealed a close-to-linear correlation with the entire spectrum of degeneration. Surface integrity should therefore be assessed by a combination of parameters to improve current diagnostic accuracy in the determination of cartilage degeneration.
Author(s)
Brill, Nicolai
Riedel, Jörn
Rath, Björn
Tingart, Markus
Jahr, Holger
Betsch, Marcel
Quack, Valentin
Pufe, Thomas
Schmitt, Robert  
Nebelung, Sven
Journal
Biomedical optics express. Online journal  
Open Access
Link
Link
DOI
10.1364/BOE.6.002398
Language
English
Fraunhofer-Institut für Produktionstechnologie IPT  
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