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  4. A switching lung mechanics model for detection of expiratory flow limitation
 
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2024
Journal Article
Title

A switching lung mechanics model for detection of expiratory flow limitation

Other Title
Ein schaltbares Lungenmechanikmodell zur Erkennung der exspiratorischen Flusslimitierung
Abstract
Expiratory flow limitation (EFL) is an often unrecognized clinical condition with a multitude of negative implications. A mathematical EFL model is proposed to detect flow limitations automatically. The EFL model is a switching one-compartment lung mechanics model with a volume-dependent airway resistance to simulate the dynamic behavior during expiration. The EFL detection is based on a breath-by-breath model parameter identification and validated on clinical data of mechanically ventilated patients. In the severe flow limitation group 93.9 % ± 5 % and in the no limitation group 10.2 % ± 13.7 % of the breaths are detected as EFL. Based on the high detection rate of EFL, these results support the usefulness of the EFL detection. It is a first step toward an automated detection of EFL in clinical applications and may help to reduce underdiagnosis of EFL.
Author(s)
Hennigs, Carlotta
Bilda, Franziska
Graßhoff, Jan  
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Walterspacher, Stephan
Rostalski, Philipp  
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Journal
Automatisierungstechnik : AT  
DOI
10.1515/auto-2023-0206
Language
English
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Keyword(s)
  • computational model

  • EFL

  • flow limitation

  • lung mechanics

  • mechanical ventilation

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