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  4. Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging
 
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2024
Journal Article
Title

Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging

Abstract
Background: Combining magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH) offers the ability to perform localized hyperthermia and magnetic particle imaging-assisted thermometry of hyperthermia treatment. This allows precise regional selective heating inside the body without invasive interventions. In current MPI-MFH platforms, separate systems are used, which require object transfer from one system to another. Here, we present the design, development and evaluation process for integrable MFH platforms, which extends a commercial MPI scanner with the functionality of MFH.
Methods: The biggest issue of integrating magnetic fluid hyperthermia platforms into a magnetic particle imaging system is the magnetic coupling of the devices, which induces high voltage in the imaging system, and is harming its components. In this paper, we use a self-compensation approach derived from heuristic algorithms to protect the magnetic particle imaging scanner. The integrable platforms are evaluated regarding electrical and magnetic characteristics, cooling capability, field strength, the magnetic coupling to a replica of the magnetic particle imaging system's main solenoid and particle heating.
Results: The MFH platforms generate suitable magnetic fields for the magnetic heating of particles and are compatible with a commercial magnetic particle imaging scanner. In combination with the imaging system, selective heating with a gradient field and steerable heating positioning using the MPI focus fields are possible.
Conclusion: The proposed MFH platforms serve as a therapeutic tool to unlock the MFH functionality of a commercial magnetic particle imaging scanner, enabling its use in future preclinical trials of MPI-guided, spatially selective magnetic hyperthermia therapy.
Author(s)
Behrends, André  
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Wei, Huimin
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Neumann, Alexander
University of Lübeck, Institute of Medical Engineering (IMT)
Friedrich, Thomas  
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Bakenecker, Anna Christin
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Franke, Jochen
Bruker BioSpin MRI GmbH, Preclinical Imaging Division
Sajjamark, Kulthisa
Bruker BioSpin MRI GmbH, Preclinical Imaging Division
Buchholz, Oliver
University Medical Center Freiburg, Faculty of Medicine
Bär, Sébastien
University Medical Center Freiburg, Faculty of Medicine
Hofmann, Ulrich G.
University Medical Center Freiburg, Faculty of Medicine
Gräser, Matthias
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Buzug, Thorsten
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Journal
Nanotheranostics  
Open Access
DOI
10.7150/ntno.90360
Language
English
Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE  
Keyword(s)
  • magnetic particle imaging

  • magnetic fluid hyperthermia

  • imaging-guided treatment

  • theranostics

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