Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells
Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
bInstitute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology,Senftenberg, Germany
cInstitute for Mikrobiology und Virology, Medizinische Hochschule Brandenburg Theodor Fontane, Senftenberg, Germany
Jung, Ernst Michael
Department of Radiology and Interdisciplinary Ultrasound Department, University Hospital Regensburg, Regensburg, Germany
Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology, Senftenberg, Germany