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2023
Journal Article
Title
Cohort Profile: The LIFE-Adult-Study
Abstract
Why was the cohort set up?
Population-based cohort studies are an essential foundation for investigating associations of genetic and non-genetic risk factors with the occurrence of diseases. Several such studies have been initiated in Germany over the past decades focusing on specific phenotypes and diseases.1–5 In 2009, the Leipzig Research Centre for Civilization Diseases (LIFE) was established to set up population-based and patient-based cohorts with comprehensive molecular characterization and deep disease phenotyping programmes for a broad spectrum of common diseases. LIFE focuses on the characterization of subclinical disease phenotypes and the identification of determinants predicting their progression to clinically manifest disease. It is part of the Medical Faculty of Leipzig University, enabling the participation of clinicians, epidemiologists and methodologists researchers experienced in molecular and genetic profiling, biostatistics and bioinformatics. LIFE is funded by the European Union, the European Regional Development Fund and funds of the Free State of Saxony, Germany.
Population-based cohort studies are an essential foundation for investigating associations of genetic and non-genetic risk factors with the occurrence of diseases. Several such studies have been initiated in Germany over the past decades focusing on specific phenotypes and diseases.1–5 In 2009, the Leipzig Research Centre for Civilization Diseases (LIFE) was established to set up population-based and patient-based cohorts with comprehensive molecular characterization and deep disease phenotyping programmes for a broad spectrum of common diseases. LIFE focuses on the characterization of subclinical disease phenotypes and the identification of determinants predicting their progression to clinically manifest disease. It is part of the Medical Faculty of Leipzig University, enabling the participation of clinicians, epidemiologists and methodologists researchers experienced in molecular and genetic profiling, biostatistics and bioinformatics. LIFE is funded by the European Union, the European Regional Development Fund and funds of the Free State of Saxony, Germany.
Author(s)