Towards a genetic screening test for dyslexia allowing functional regeneration: a strategy for identification and analysis of genetic risk factors
Our aim is to develop previous terma genetic screening testnext term for previous termdyslexia, anext term severe disorder of reading and frequently of writing, affecting approx. 4% of all schoolchildren. previous termAnext term significant problem is late diagnosis resulting in previous termanext term decreased chance of functional regeneration. Our solution is an early previous termgenetic testnext term that will initiate existing early training programs. previous termGenetic dyslexianext term markers necessary for this previous termtestnext term are identified in previous termanext term microarray based fine screen supplemented by polymorphisms of highly relevant candidate genes. Validation of these markers is done by (previous termA)next term genotyping an independent cohort; (B) by characterising markers in functional magnet resonance imaging (fMRI) and electroencephalography (EEG); and (C) by characterising markers in allele specific mRNA-expression analysis or allele-specific chromatin immunoprecipitation (ChIP). The final previous termtestnext term will neither include fMRI/EEG nor expression analysis. It translates previous termgeneticnext term findings into previous termanext term clinical assay. This previous termtestnext term would allow early identification of children at risk, enabling early support resulting in functional regeneration.