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  4. Three-dimensional assessment of vascular cooling effects on hepatic microwave ablation in a standardized ex vivo model
 
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October 12, 2022
Journal Article
Title

Three-dimensional assessment of vascular cooling effects on hepatic microwave ablation in a standardized ex vivo model

Abstract
The aim of this study was a three-dimensional analysis of vascular cooling effects on microwave ablation (MWA) in an ex vivo porcine model. A glass tube, placed in parallel to the microwave antenna at distances of 2.5, 5.0 and 10.0 mm (A–V distance), simulated a natural liver vessel. Seven flow rates (0, 1, 2, 5, 10, 100, 500 ml/min) were evaluated. Ablations were segmented into 2 mm slices for a 3D-reconstruction. A qualitative and quantitative analysis was performed. 126 experiments were carried out. Cooling effects occurred in all test series with flow rates ≥ 2 ml/min in the ablation periphery. These cooling effects had no impact on the total ablation volume (p > 0.05) but led to changes in ablation shape at A–V distances of 5.0 mm and 10.0 mm. Contrary, at a A–V distance of 2.5 mm only flow rates of ≥ 10 ml/min led to relevant cooling effects in the ablation centre. These cooling effects influenced the ablation shape, whereas the total ablation volume was reduced only at a maximal flow rate of 500 ml/min (p = 0.002). Relevant cooling effects exist in MWA. They mainly depend on the distance of the vessel to the ablation centre.
Author(s)
Neizert, Christina
Do, H.N.C
Rieder, C.
Sinden, David  orcid-logo
Fraunhofer-Institut für Digitale Medizin MEVIS  
Niehues, S.M.
Vahldiek, J.L.
Lehmann, K.S.
Poch, F.G.M.
Journal
Scientific Reports  
Open Access
File(s)
Download (2.38 MB)
Rights
CC BY 4.0: Creative Commons Attribution
DOI
10.1038/s41598-022-21437-4
10.24406/publica-554
Additional full text version
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