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2021
Journal Article
Titel
Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel
Abstract
In this study, a novel approach to create arbitrarily shaped 3D hydrogel objects is presented, wherein freeform two-photon polymerization (2PP) is enabled by the combination of a photosensitive hydrogel and an intrinsic support matrix. This way, topologies without physical contact such as a highly porous 3D network of concatenated rings were realized, which are impossible to manufacture with most current 3D printing technologies. Micro-Raman and nanoindentation measurements show the possibility to control water uptake and hence tailor the Young's modulus of the structures via the light dosage, proving the versatility of the concept regarding many scaffold characteristics that makes it well suited for cell specific cell culture as demonstrated by cultivation of human induced pluripotent stem cell derived cardiomyocytes.
Author(s)
Hasselmann, Sebastian
Fraunhofer Project Center for Stem Cell Process Engineering, Wuerzburg, Germany
Hahn, Lukas
Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, University of Wuerzburg, Wuerzburg, Germany
Lorson, Thomas
Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, University of Wuerzburg, Wuerzburg, Germany
Sébastien, Isabelle
Fraunhofer Institute for Biomedical Engineering, Fraunhofer Project Center for Stem Cell Process Engineering, Wuerzburg, Germany
Beudert, Matthias
Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
Lühmann, Tessa
Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
Neubauer, Julia C.
Fraunhofer Institute for Biomedical Engineering, Fraunhofer Project Center for Stem Cell Process Engineering, Wuerzburg, Germany
Luxenhofer, Robert
Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, University of Wuerzburg, Wuerzburg, Germany
