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A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro

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cris.virtual.departmentFraunhofer-Institut für Betriebsfestigkeit und Systemzuverlässigkeit LBF
cris.virtual.departmentFraunhofer-Institut für Silicatforschung ISC
cris.virtual.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.orcid0000-0002-6343-0505
cris.virtualsource.departmente4309f7a-f013-47f1-b4f9-73818fb35b56
cris.virtualsource.departmentf45565bc-b4cc-401d-918f-d1640ed6694a
cris.virtualsource.orcide4309f7a-f013-47f1-b4f9-73818fb35b56
cris.virtualsource.orcidf45565bc-b4cc-401d-918f-d1640ed6694a
crisou.acronymISC
dc.contributor.authorWeigel, Tobias
dc.contributor.authorSchmitz, Tobias
dc.contributor.authorPfister, Tobias
dc.contributor.authorGaetzner, Sabine
dc.contributor.authorJannasch, Maren
dc.contributor.authorAl-Hijailan, Reem
dc.contributor.authorSchürlein, Sebastian
dc.contributor.authorSuliman, Salwa
dc.contributor.authorMustafa, Kamal
dc.contributor.authorHansmann, Jan
dc.date.accessioned2022-03-05T18:18:14Z
dc.date.available2022-03-05T18:18:14Z
dc.date.issued2018
dc.description.abstractPacemaker systems are an essential tool for the treatment of cardiovascular diseases. However, the immune system's natural response to a foreign body results in the encapsulation of a pacemaker electrode and an impaired energy efficiency by increasing the excitation threshold. The integration of the electrode into the tissue is affected by implant properties such as size, mechanical flexibility, shape, and dimensionality. Three-dimensional, tissue-like electrode scaffolds render an alternative to currently used planar metal electrodes. Based on a modified electrospinning process and a high temperature treatment, a conductive, porous fiber scaffold was fabricated. The electrical and immunological properties of this 3D electrode were compared to 2D TiN electrodes. An increased surface of the fiber electrode compared to the planar 2D electrode, showed an enhanced electrical performance. Moreover, the migration of cells into the 3D construct was observed and a lower inflammatory response was induced. After early and late in vivo host response evaluation subcutaneously, the 3D fiber scaffold showed no adverse foreign body response. By embedding the 3D fiber scaffold in human cardiomyocytes, a tissue-electrode hybrid was generated that facilitates a high regenerative capacity and a low risk of fibrosis. This hybrid was implanted onto a spontaneously beating, tissue-engineered human cardiac patch to investigate if a seamless electronic-tissue interface is generated. The fusion of this hybrid electrode with a cardiac patch resulted in a mechanical stable and electrical excitable unit. Thereby, the feasibility of a seamless tissue-electrode interface was proven.
dc.description.startpageArt. 14545, 13 S.
dc.description.volume8
dc.identifier.doi10.1038/s41598-018-32790-8
dc.identifier.urihttps://publica.fraunhofer.de/handle/publica/254509
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.subjectHerzschrittmacher
dc.subjectscaffold
dc.subjectElektrode
dc.subjecttissue engineering
dc.subject.ddc666
dc.titleA three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro
dc.typejournal article
dspace.entity.typePublication
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oairecerif.author.affiliationFraunhofer-Institut für Silicatforschung ISC
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oairecerif.author.affiliationFraunhofer-Institut für Silicatforschung ISC
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publica.bestOA.landinghttps://doi.org/10.1038/s41598-018-32790-8
publica.bestOA.pdfhttps://www.nature.com/articles/s41598-018-32790-8.pdf
publica.date16.10.2018
publica.fhg.instituteFraunhofer-Institut für Silicatforschung ISC
publica.fhg.location#PLACEHOLDER_PARENT_METADATA_VALUE#
publica.identifier.urihttps://www.nature.com/articles/s41598-018-32790-8.pdf
publica.mig.recordnumber266657
publica.oa.url10.1038/s41598-018-32790-8
publica.peerreviewedUlrichs
publica.peerreviewedScopus
publica.peerreviewedSCOPUS
publica.rights.oaOpen Access
publica.rights.oaStatusgold
publica.rights.oaUnpaywallTrue
publica.rights.timestamp2025-07-02 06:12:43.379900

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