• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Localization and functional characterization of the pathogenesis-related proteins Rbe1p and Rbt4p in Candida albicans
 
  • Details
  • Full
Options
2018
Journal Article
Title

Localization and functional characterization of the pathogenesis-related proteins Rbe1p and Rbt4p in Candida albicans

Abstract
Members of the Cysteine-rich secretory protein, Antigen 5 and Pathogenesis-related 1 (CAP) protein superfamily are important virulence factors in fungi but remain poorly characterized on molecular level. Here, we investigate the cellular localization and molecular function of Rbe1p and Rbt4p, two CAP family members from the human pathogen Candida albicans. We unexpectedly found that Rbe1p localizes to budding sites of yeast cells in a disulfide bond-dependent manner. Furthermore, we show that Rbe1p and Rbt4p bind free cholesterol in vitro and export cholesteryl acetate in vivo. These findings suggest a previously undescribed role for Rbe1p in cell wall-associated processes and a possible connection between the virulence attributes of fungal CAP proteins and sterol binding.
Author(s)
Bantel, Y.  
Darwiche, Rabih
Rupp, Steffen  
Schneiter, Roger
Sohn, Kai  
Journal
PLoS one. Online journal  
Open Access
DOI
10.1371/journal.pone.0201932
Additional full text version
Landing Page
Language
English
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB  
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024