Now showing 1 - 2 of 2
  • Publication
    Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis
    ( 2016)
    Kim, S.H.
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    Lee, H.
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    Hwang, D.H.
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    Seo, D.H.
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    Kim, H.S.
    ;
    Cho, S.
    Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 mA, 50 mA, and 400 mA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.
  • Publication
    Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
    ( 2015)
    Kim, E.C.
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    Kim, S.H.
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    Piao, S.J.
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    Kim, T.J.
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    Bae, K.
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    Kim, H.S.
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    Hong, S.S.
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    Lee, B.I.
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    Nam, M.
    Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors. Inhibition of angiogenesis is currently perceived as one of the most promising strategies for the blockage of tumor growth. In this study, we investigated the effects of Acer tegmentosum maxim water extract (ATME) on angiogenesis and its underlying signal mechanism. We studied the antiangiogenic activity of ATME by using human umbilical vein endothelial cells (HUVECs). ATME strongly inhibited VEGF-induced endothelial cell proliferation, migration, invasion, and tube formation, as well as vessel sprouting in a rat aortic ring sprouting assay. Moreover, we found that the p44/42 mitogen activated protein (MAP) kinase signaling pathway is involved in the inhibition of angiogenesis by ATME. Moreover, when we performed the in vivo matrigel plug assay, VEGF-induced angiogenesis was potently reduced when compared to that for the control group. Taken together, these results suggest that ATME exhibits potent antiangiogenic activity in vivo and in vitro and that these effects are regulated by the extracellular regulated kinase (ERK) pathway.