Yonsei Fraunhofer IZFP Medical Device Lab YFMED

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  • Publication
    Inhibited apoptosis of C2C12 myoblasts by a eupatorium chinense var. simplicifolium root extract
    ( 2013)
    Lee, J.-H.
    ;
    Jung, M.-H.
    ;
    Lee, Y.-H.
    ;
    Shin, Y.
    ;
    Kim, H.-S.
    ;
    Schreiber, J.
    ;
    Kim, T.-J.
    We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C2C12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O 2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUCpre- treated C2C12 myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.