Inhibited apoptosis of C2C12 myoblasts by a eupatorium chinense var. simplicifolium root extract
2013,
Lee, J.-H.,
Jung, M.-H.,
Lee, Y.-H.,
Shin, Y.,
Kim, H.-S.,
Schreiber, J.,
Kim, T.-J.
We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C2C12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O 2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUCpre- treated C2C12 myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.