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Highly integrated polymer-based technology platform for in-vitro diagnostics

2008 , Otto, Thomas , Nestler, Jörg , Morschhauser, Andreas , Schüller, Martin , Geßner, T. , Krissler, Jan , Ebling, Frank , Wegener, Michael , Grzesiak, Andrzej , Burgard, Matthias , Brandenburg, Albrecht , Sulz, Gerd , Nebling, Eric , Hintsche, Rainer , Wirth, Ingo , Godlinski, Dirk , Tovar, Günter E.M. , Weber, Achim , Ehrentreich-Förster, Eva , Gajovic-Eichelmann, Nenad , Bier, Frank F.

Systems for in-vitro diagnostics are of great interest especially in the point-of-care diagnostic market. Specialized integrated approaches have already been developed and successfully marketed, but were mainly focused on basic blood parameter determination. This paper describes a new, more flexible approach for an in-vitro diagnostic cartridge, which is able to hold different types of sensors (optical and electrochemical), integrated reagents as well as integrated microfluidic actuators. The platform will be capable of running both protein and nucleic acid analysis.