Chen, ChenChenChenSingh, AartiAartiSinghLiu, WeiguoWeiguoLiuMüller-Wittig, Wolfgang K.Wolfgang K.Müller-WittigMitchell, W.W.MitchellSchmidt, BertilBertilSchmidt2022-03-102022-03-102007https://publica.fraunhofer.de/handle/publica/35606710.1142/9789812708823_0013Comparative genomics provides a powerful tool for studying evolutionary changes among organisms. We have designed a new tool, called Phenotype Genotype Explorer to nominate candidate genes responsible for a given phenotype. There are huge datasets involved which makes this approach impractical on traditional computer architectures leading to prohibitively long runtimes. In this paper, we present a computational architecture based on a desktop grid environment and commodity graphics hardware to significantly accelerate the comparative genomics application. We present the deployment and evaluation of this approach on our grid testbed for the comparison of microbial genomes.endesktop gridgraphics hardwareGraphics Processing Unit (GPU)sequence alignment006conference paper