Asprion, NorbertNorbertAsprionRitter, JulianeJulianeRitterBöttcher, RogerRogerBöttcherBortz, MichaelMichaelBortz2022-03-132022-03-132018https://publica.fraunhofer.de/handle/publica/40155810.1016/B978-0-444-64235-6.50010-32-s2.0-85049352506The quality of process optimization depends on model parameters. The use of operating data from mini-, pilot or production plants can help to improve model agreement with operation. To support the design of experiments (DoE) in plants with many operability limitations a model-based DoE was implemented into a flowsheet simulator. In this contribution, the implementation of the method is described and its use for the identification of kinetics is demonstrated for a cumene process.en003006519conference paper