Hähnel, TomTomHähnelRaschka, TamaraTamaraRaschkaKlucken, JochenJochenKluckenGlaab, EnricoEnricoGlaabCorvol, Jean ChristopheJean ChristopheCorvolFalkenburger, Björn H.Björn H.FalkenburgerFröhlich, HolgerHolgerFröhlich2025-04-142025-04-142025https://publica.fraunhofer.de/handle/publica/48655710.1038/s41531-025-00923-22-s2.0-105001644947PD patients present with diverse symptoms, complicating timely diagnosis. We analyzed 1124 PD trajectories using a novel model-based approach to estimate whether diagnosis was early or late compared to cohort averages. Higher age, specific non-motor symptoms, and fast disease progression were linked to later diagnosis, while gait impairment led to earlier diagnosis. Our findings are in line with a biological definition of PD that extends beyond classical motor symptoms.entruejournal article