Lai, ChentingChentingLaiMesserschmidt, BernhardBernhardMesserschmidtReichwald, KarlKarlReichwaldFlämig, SvenSvenFlämigEidam, TinoTinoEidamStutzki, FabianFabianStutzkiCalvarese, MatteoMatteoCalvareseBae, HyeonsooHyeonsooBaeMeyer-Zedler, TobiasTobiasMeyer-ZedlerSchmitt, MichaelMichaelSchmittGross, HerbertHerbertGrossHoffmann, FranziskaFranziskaHoffmannGuntinas-Lichius, OrlandoOrlandoGuntinas-LichiusPopp, Jürgen R.Jürgen R.Popp2023-08-302023-08-302023https://publica.fraunhofer.de/handle/publica/44899510.1117/12.26502132-s2.0-85159761191Here, we present a new handheld multiphoton endomicroscopic system designed for tumor diagnosis in the head and neck region. It consists of an approx. 25 cm long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view ⪆ 600 µm for coherent anti-Stokes Raman scattering (CARS) and other nonlinear imaging modalities by a non-descanned detection, and using a descanned confocal imaging channel to detect light from tissue labeled with indocyanine green (ICG). Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation which was considered in the optical design of the probe.enCARS and multiphoton endoscopyfs laser ablationindocyanine green imaginglaryngeal cancernon-linear endomicroscopyconference paper