Coproduction of EPA and Fucoxanthin with P. tricornutum - A Promising Approach for Up- and Downstream Processing

Derwenskus, FelixFelixDerwenskusSchäfer, BenjaminBenjaminSchäferMüller, JanJanMüllerFrick, KonstantinKonstantinFrickGille, AndreaAndreaGilleBriviba, KarlisKarlisBrivibaSchmid-Staiger, UlrikeUlrikeSchmid-StaigerHirth, ThomasThomasHirth2022-03-062022-03-062020https://publica.fraunhofer.de/handle/publica/26550710.1002/cite.202000046Eicosapentaenoic acid (EPA) and fucoxanthin, a carotenoid, provide a broad variety of health benefits in human nutrition. In this study, an up- and downstream process for the coproduction of EPA and fucoxanthin using the diatom Phaeodactylum tricornutum in flat-panel airlift photobioreactors is proposed. The approach represents a promising alternative to conventional sources for both compounds, viz. marine fish and macroalgae. The productivity as well as the biomass-specific product content were optimized during cultivation. Subsequently, both compounds were extracted, separated and purified using pressurized liquids.eneicosapentaenoic acidcarotenoiddiatomlight availabilitypressurized liquid extraction660610620Coproduction of EPA and Fucoxanthin with P. tricornutum - A Promising Approach for Up- and Downstream Processingjournal article