Groeber-Becker, FlorianFlorianGroeber-BeckerHoleiter, M.M.HoleiterHampel, M.M.HampelHinderer, SvenjaSvenjaHindererSchenke-Layland, KatjaKatjaSchenke-Layland2022-03-042022-03-042011https://publica.fraunhofer.de/handle/publica/22554510.1016/j.addr.2011.01.005Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.en660615journal article