Tautorat, C.C.TautoratKoester, P.J.P.J.KoesterHeld, J.J.HeldGaspar, J.J.GasparRuther, P.P.RutherPaul, O.O.PaulCismak, A.A.CismakHeilmann, A.A.HeilmannGimsa, J.J.GimsaBeikrich, H.H.BeikrichJonas, L.L.Jonas2022-03-102022-03-102008https://publica.fraunhofer.de/handle/publica/360744We present a new sensor chip system for intracellular potential measurements of adherently growing cells using micro-structured needle electrode (MNE) arrays. Existing methods for intracellular investigations are time-consuming, tedious or limited to the analysis of suspended cells. However, most biological cells grow adherently. To overcome these methodological limitations a novel technique, local micro-invasive needle electroporation (LOMINE) in MNE arrays, has been developed. LOMINE opens the cell membrane for introducing a MNE into the cytoplasm. This paper describes the fabrication process of the MNE-arrey chips and first cell electroporation experiments.enelectroporationpatch-clampmembrane potentialLab-on-a-Chip620conference paper