Kessler, A.A.KesslerVillmann, C.C.VillmannSahin, H.H.SahinPischetsrieder, M.M.PischetsriederBüttner, A.A.Büttner2022-03-132022-03-132014https://publica.fraunhofer.de/handle/publica/39835310.1016/B978-0-12-398549-1.00012-XSideritis spp. is a member of the Labiateae plant family, and used for tea infusions with claimed sedative properties. To clarify if the volatile fractions of the plant material can exert a sedative effect via g-aminobutyric acid (GABA) signaling, a dichloromethane (DCM) aroma extract of the aerial parts was prepared. The volatile fraction was separated via solvent assisted flavor evaporation (SAFE) distillation. In electrophysiological recordings using the two-electrode voltage clamp technique (TEVC), the plant extract of Sideritis species showed potentiation effects of the maximal GABA-induced response on GABAA receptors comparable to those of lavender.en664688conference paper