Hoymann, H.-G.H.-G.HoymannBuschmann, J.J.BuschmannErnst, H.H.ErnstBartsch, W.W.BartschCreutzenberg, O.O.CreutzenbergBellmann, B.B.BellmannDasenbrock, C.C.DasenbrockKoch, W.W.KochPreiß, A.A.PreißHeinrich, U.U.Heinrich2022-03-032022-03-031997https://publica.fraunhofer.de/handle/publica/190058Female Wistar rats were exposed in 6 m³ id groups and in increase in maternal lung weight in the high dose group. Consequently, a "no embryotoxic effect level" of 3 mg/m³ was determined. MDI metabolites occured in decreasing concentrations in the placenta, the fetus and the amniotic fluid. Further investigations are necessary to clarify the mechanism of the MDI-dependent tumor induction in the respiratory tract of the rat.en4,4'-methylenediphenyldiisocyanateinhalation toxicologyrat615610620journal article