Sack, M.M.SackVaquero-Martin, C.C.Vaquero-MartinFischer, R.R.Fischer2022-03-082022-03-082005https://publica.fraunhofer.de/handle/publica/307094EP 1529844 A UPAB: 20050608 NOVELTY - Altering properties and/or generating novel properties such as accumulation ability, stability or integrity, etc., of a natural or a recombinant target protein, by expressing a gene encoding target protein and a gene encoding specific binding partner for target protein to the natural/recombinant target protein, expressing interactions between target protein and binding partner and linking properties of binding partner to target protein. DETAILED DESCRIPTION - Altering (M1) the properties and/or generating novel properties of a natural or a recombinant target protein which is the target protein, where the properties are chosen from accumulation ability, stability and/or integrity, cellular localization, posttranslational modification, amenability to isolation, purification and phase partitioning, involves providing a specific binding partner to the natural or recombinant target protein comprising a tag and/or a targeting sequence, by expressing a gene coding for the target protein in a non-human host, expressing a gene encoding the specific binding partner for the target protein or providing the specific binding partner for the target protein in a different manner, interactions between the target protein and the binding partner yielding a complex, and thus linking the properties of the binding partner to the target protein, resulting in a target protein with altered properties or novel properties. USE - (M1) is useful for altering the properties and/or generating novel properties of a natural or a recombinant target protein, where the target protein is therapeutically active or potentially therapeutically active protein, a protein used for diagnostic purposes and/or a protein for non-medical use (claimed).de608570610620660patent2003-4884402003-22397