Kruse, C.C.KruseRapoport, D.D.Rapoport2022-03-082022-03-082007https://publica.fraunhofer.de/handle/publica/308204(A1) Die Erfindung betrifft eine therapeutische Zusammensetzung zur Behandlung einer Autoimmunerkrankung bei einem Patienten, umfassend mindestens ein Autoimmunreaktionen ausloesendes Antigen sowie Verfahren und Vorrichtungen zur autologen Antikoerper- und Antigenproduktion. In einer bevorzugten Ausfuehrungsform der Erfindung wird das Antigen von Zellen produziert, die durch Differenzierung von adulten Stammzellen des Patienten mit der Autoimmunerkrankung entstanden sind.DE 102007028687 A1 UPAB: 20090220 NOVELTY - Composition for treating an autoimmune disease in an individual comprises an autologous antigen that induces an autoimmune reaction. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) producing a composition for treating an autoimmune disease in an individual by preparing an antigen composition using tissue and antibodies from the individual; (2) producing an immunoaffinity matrix comprising immobilized antibodies specific for a target antigen by preparing an antigen-containing protein composition, separating the composition is a gel matrix, transferring the separated proteins to a blotting membrane by electrophoresis through a second matrix, identifying a target antigen by binding to a labeled antibody, correlating the position of the target antigen on the membrane with a region in the second matrix, removing antigen-free regions from the second matrix, contacting the antigen-containing region with an antibody composition from the serum of an individual having antibodies specific for the target antigen, eluting nonspecific antibodies, breaking the antigen-antibody bond, removing the antigen by elution and adding a crosslinking agent to crosslink the antibodies in the matrix; (3) device for producing an immunoaffinity matrix, comprising a protein separation gel separated from a blotting membrane by a porous carrier matrix that transfers protein fractions from the gel to the membrane without further separation and is suitable for immobilizing antbodies. ACTIVITY - Immunosuppressive; Dermatological; Antiinflammatory; Antidiabetic; Antipsoriatic; Neuroprotective. No biological data given. MECHANISM OF ACTION - Vaccine. USE - Treating autoimmune diseases, especially lupus erythematosus, type I diabetes, Crohn's disease, psoriasis, neurodermatitis and multiple sclerosis.depatent102007028687